Romero picked up a knee injury while playing for Argentina against Spain last month, according to ESPN FC.
Romero did not travel with the team scheduled to take on Bournemouth on Wednesday night's English Premier League clash.
Romero usually is in goal for FA Cup matches but if he is not available, first-choice David De Gea should take his place under the bar against Spurs.
Meanwhile, Luke Shaw, Daley Blind, Marouane Fellaini and Matteo Darmian have all been included in United's squad for the crunch Cup game.
Shaw has yet to take a firm decision about his future at Manchester United and will assess his options this summer, according to ESPN FC sources.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
