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Disrupting tiny liver protein can cause heart disease

Disrupting tiny liver protein can cause heart disease

New York, June 12 (IANS) Scientists have identified for the first time a tiny liver protein that when disrupted can lead to cardiovascular disease as well as fatty liver disease -- a precursor to cancer.

Lipoproteins (VLDL) are crucial for healthy liver function. Normal VLDL secretion must be kept in a delicate balance as too little VLDL secretion causes fatty liver and, potentially, liver cancer.

Lipoproteins are also known to increase cholesterol levels, a risk factor for plaque buildup in the arteries.

 

In a study, published recently in the Journal of Biological Chemistry, Shadab Siddiqi from University of Central Florida found a tiny protein -- called a Small Valosin-Containing Protein Interacting Protein (SVIP) -- that regulates how much VLDL is secreted into the blood.

"SVIP in the liver must be regulated properly to ensure optimum health," Siddiqi said.

He equates the operation of the tiny protein to a manually operated car. "To run smoothly, the driver must synchronise the gas pedal and the clutch. If the two aren't synchronised, the car doesn't move easily; it has fits and starts and ultimately stalls," he said.

The study also suggests that high levels of myristic acid in the diet -- through animal and dairy fats -- keep SVIP from properly regulating the liver's secretion of VLDL.

"These findings suggest that our diet modulates the complex molecular processes that have profound effects on our health and lifespan," Siddiqi explained.

"The challenge will be in creating a therapy that does not impact the liver's many other functions," he added.

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Disrupting tiny liver protein can cause heart disease

About Gopi Adusumilli

Gopi Adusumilli is a Programmer at Excellus Blue Cross Blue Shield. He is the editor of SocialNews.XYZ and President of AGK Fire Inc. He enjoys designing websites, developing mobile applications and publishing news articles on current events from various authenticated news sources. When it comes to writing he likes to write about current world politics and Indian Movies. His future plans include developing SocialNews.XYZ into a News website that has no bias or judgment towards any. He can be reached at gopi@socialnews.xyz

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