ng_attempts; $rval = $this->contact_service( 'ping', array( 'args' => $vaultpress_pings ) ); if ( $rval || $ping_attempts >= 3 ) break; if ( !$rval ) usleep(500000); } while ( true ); if ( !$rval ) { if ( $this->get_option( 'connection_error_code' ) !== -8 ) { // Do not save pings when the subscription is inactive. $__vp_recursive_ping_lock = true; $this->ai_ping_insert( serialize( $vaultpress_pings ) ); } } $this->reset_pings(); if ( $close_wpdb ) { $wpdb->__destruct(); unset( $wpdb ); } return $rval; } function resolve_content_dir() { // Take the easy way out if ( defined( 'WP_CONTENT_DIR' ) ) { if ( substr( WP_CONTENT_DIR, -1 ) != DIRECTORY_SEPARATOR ) return WP_CONTENT_DIR . DIRECTORY_SEPARATOR; return WP_CONTENT_DIR; } // Best guess if ( defined( 'ABSPATH' ) ) { if ( substr( ABSPATH, -1 ) != DIRECTORY_SEPARATOR ) return ABSPATH . DIRECTORY_SEPARATOR . 'wp-content' . DIRECTORY_SEPARATOR; return ABSPATH . 'wp-content' . DIRECTORY_SEPARATOR; } // Run with a solid assumption: WP_CONTENT_DIR/vaultpress/vaultpress.php return dirname( __DIR__ ) . DIRECTORY_SEPARATOR; } function resolve_upload_path() { $upload_path = false; $upload_dir = wp_upload_dir(); if ( isset( $upload_dir['basedir'] ) ) $upload_path = $upload_dir['basedir']; // Nothing recorded? use a best guess! if ( !$upload_path || $upload_path == realpath( ABSPATH ) ) return $this->resolve_content_dir() . 'uploads' . DIRECTORY_SEPARATOR; if ( substr( $upload_path, -1 ) != DIRECTORY_SEPARATOR ) $upload_path .= DIRECTORY_SEPARATOR; return $upload_path; } function load_first( $value ) { $value = array_unique( $value ); // just in case there are duplicates return array_merge( preg_grep( '/vaultpress\.php$/', $value ), preg_grep( '/vaultpress\.php$/', $value, PREG_GREP_INVERT ) ); } function is_multisite() { if ( function_exists( 'is_multisite' ) ) return is_multisite(); return false; } function is_main_site() { if ( !function_exists( 'is_main_site' ) || !$this->is_multisite() ) return true; return is_main_site(); } function is_registered() { $key = $this->get_option( 'key' ); $secret = $this->get_option( 'secret' ); return !empty( $key ) && !empty( $secret ); } function clear_connection() { $this->delete_option( 'connection' ); $this->delete_option( 'connection_error_code' ); $this->delete_option( 'connection_error_message' ); $this->delete_option( 'connection_test' ); } function site_url() { $site_url = ''; // compatibility for WordPress MU Domain Mapping plugin if ( defined( 'DOMAIN_MAPPING' ) && DOMAIN_MAPPING && ! function_exists( 'domain_mapping_siteurl' ) ) { if ( !function_exists( 'is_plugin_active' ) ) require_once ABSPATH . '/wp-admin/includes/plugin.php'; $plugin = 'wordpress-mu-domain-mapping/domain_mapping.php'; if ( is_plugin_active( $plugin ) ) include_once( WP_PLUGIN_DIR . '/' . $plugin ); } if ( function_exists( 'domain_mapping_siteurl' ) ) $site_url = domain_mapping_siteurl( false ); if ( empty( $site_url ) ) $site_url = site_url(); return $site_url; } /** * Sync the VaultPress options to WordPress.com if the Jetpack plugin is active. */ function sync_jetpack_options() { if ( class_exists( 'Jetpack_Sync' ) && method_exists( 'Jetpack_Sync', 'sync_options' ) && defined( 'JETPACK__VERSION' ) && version_compare( JETPACK__VERSION, '4.1', '<' ) ) { Jetpack_Sync::sync_options( __FILE__, $this->auto_register_option, $this->option_name ); } } /** * Add the VaultPress options to the Jetpack options management whitelist. * Allows Jetpack to register VaultPress options automatically. * * @param array $options The list of whitelisted option names. * * @return array The updated whitelist */ function add_to_jetpack_options_whitelist( $options ) { $options[] = $this->option_name; $options[] = $this->auto_register_option; return $options; } /** * When the VaultPress auto-register option is updated, run the registration call. * * This should only be run when the option is updated from the Jetpack/WP.com * API call, and only if the new key is different than the old key. * * @param mixed $old_value The old option value, or the option name (if add_option). * @param mixed $value The new option value. */ function updated_auto_register_option( $old_value, $value ) { // Not an API call or CLI call if ( ! class_exists( 'WPCOM_JSON_API_Update_Option_Endpoint' ) && ! ( defined( 'WP_CLI' ) && WP_CLI ) ) { return; } remove_action( "update_option_{$this->auto_register_option}", array( $this, 'updated_auto_register_option' ) ); $defaults = array( 'key' => false, 'action' => 'register', // or `response` 'status' => 'working', 'error' => false, ); // `wp_parse_args` uses arrays, might as well be explicit about it. $registration = (array) json_decode( $value ); $registration = wp_parse_args( $registration, $defaults ); // If we have a working connection, don't update the key. if ( $this->check_connection( true ) ) { $registration['action'] = 'response'; $registration['error'] = 'VaultPress is already registered on this site.'; update_option( $this->auto_register_option, json_encode( $registration ) ); return; } if ( ! $registration['key'] ) { return; } $registration['action'] = 'response'; $response = $this->register( $registration['key'] ); if ( is_wp_error( $response ) ) { $registration['status'] = 'broken'; $registration['error'] = $response->get_error_message(); } else if ( $this->get_option( 'connection_error_code' ) ) { $registration['status'] = 'broken'; $registration['error'] = $this->get_option( 'connection_error_message' ); } else { $registration['error'] = false; } update_option( $this->auto_register_option, json_encode( $registration ) ); } function add_global_actions_and_filters() { add_action( 'init', array( $this, 'sync_jetpack_options' ), 0, 99 ); add_filter( 'jetpack_options_whitelist', array( $this, 'add_to_jetpack_options_whitelist' ) ); add_action( "update_option_{$this->auto_register_option}", array( $this, 'updated_auto_register_option' ), 10, 2 ); add_action( "add_option_{$this->auto_register_option}", array( $this, 'updated_auto_register_option' ), 10, 2 ); add_action( 'admin_enqueue_scripts', array( $this, 'styles' ) ); } function add_admin_actions_and_filters() { add_action( 'admin_init', array( $this, 'admin_init' ) ); add_action( 'admin_menu', array( $this, 'admin_menu' ), 5 ); # Priority 5, so it's called before Jetpack's admin_menu. add_action( 'admin_head', array( $this, 'admin_head' ) ); } function add_listener_actions_and_filters() { add_action( 'admin_bar_menu', array( $this, 'toolbar' ), 999 ); // Comments add_action( 'delete_comment', array( $this, 'comment_action_handler' ) ); add_action( 'wp_set_comment_status', array( $this, 'comment_action_handler' ) ); add_action( 'trashed_comment', array( $this, 'comment_action_handler' ) ); add_action( 'untrashed_comment', array( $this, 'comment_action_handler' ) ); add_action( 'wp_insert_comment', array( $this, 'comment_action_handler' ) ); add_action( 'comment_post', array( $this, 'comment_action_handler' ) ); add_action( 'edit_comment', array( $this, 'comment_action_handler' ) ); // Commentmeta add_action( 'added_comment_meta', array( $this, 'commentmeta_insert_handler' ), 10, 2 ); add_action( 'updated_comment_meta', array( $this, 'commentmeta_modification_handler' ), 10, 4 ); add_action( 'deleted_comment_meta', array( $this, 'commentmeta_modification_handler' ), 10, 4 ); // Users if ( $this->is_main_site() ) { add_action( 'user_register', array( $this, 'userid_action_handler' ) ); add_action( 'password_reset', array( $this, 'userid_action_handler' ) ); add_action( 'profile_update', array( $this, 'userid_action_handler' ) ); add_action( 'user_register', array( $this, 'userid_action_handler' ) ); add_action( 'deleted_user', array( $this, 'userid_action_handler' ) ); } // Usermeta if ( $this->is_main_site() ) { // Keeping these action hooks for backward compatibility add_action( 'added_usermeta', array( $this, 'usermeta_action_handler' ), 10, 4 ); add_action( 'update_usermeta', array( $this, 'usermeta_action_handler' ), 10, 4 ); add_action( 'delete_usermeta', array( $this, 'usermeta_action_handler' ), 10, 4 ); add_action( 'added_user_meta', array( $this, 'usermeta_action_handler' ), 10, 4 ); add_action( 'update_user_meta', array( $this, 'usermeta_action_handler' ), 10, 4 ); add_action( 'delete_user_meta', array( $this, 'usermeta_action_handler' ), 10, 4 ); } // Posts add_action( 'delete_post', array( $this, 'post_action_handler' ) ); add_action( 'trash_post', array( $this, 'post_action_handler' ) ); add_action( 'untrash_post', array( $this, 'post_action_handler' ) ); add_action( 'edit_post', array( $this, 'post_action_handler' ) ); add_action( 'save_post', array( $this, 'post_action_handler' ) ); add_action( 'wp_insert_post', array( $this, 'post_action_handler' ) ); add_action( 'edit_attachment', array( $this, 'post_action_handler' ) ); add_action( 'add_attachment', array( $this, 'post_action_handler' ) ); add_action( 'delete_attachment', array( $this, 'post_action_handler' ) ); add_action( 'private_to_publish', array( $this, 'post_action_handler' ) ); add_action( 'wp_restore_post_revision', array( $this, 'post_action_handler' ) ); // Postmeta add_action( 'added_post_meta', array( $this, 'postmeta_insert_handler' ), 10, 4 ); add_action( 'update_post_meta', array( $this, 'postmeta_modification_handler' ), 10, 4 ); add_action( 'updated_post_meta', array( $this, 'postmeta_modification_handler' ), 10, 4 ); add_action( 'delete_post_meta', array( $this, 'postmeta_modification_handler' ), 10, 4 ); add_action( 'deleted_post_meta', array( $this, 'postmeta_modification_handler' ), 10, 4 ); add_action( 'added_postmeta', array( $this, 'postmeta_action_handler' ), 10, 3 ); add_action( 'update_postmeta', array( $this, 'postmeta_action_handler' ), 10, 3 ); add_action( 'delete_postmeta', array( $this, 'postmeta_action_handler' ), 10, 3 ); // Links add_action( 'edit_link', array( $this, 'link_action_handler' ) ); add_action( 'add_link', array( $this, 'link_action_handler' ) ); add_action( 'delete_link', array( $this, 'link_action_handler' ) ); // Taxonomy add_action( 'created_term', array( $this, 'term_handler' ), 2 ); add_action( 'edited_terms', array( $this, 'term_handler' ), 2 ); add_action( 'delete_term', array( $this, 'term_handler' ), 2 ); add_action( 'edit_term_taxonomy', array( $this, 'term_taxonomy_handler' ) ); add_action( 'delete_term_taxonomy', array( $this, 'term_taxonomy_handler' ) ); add_action( 'edit_term_taxonomies', array( $this, 'term_taxonomies_handler' ) ); add_action( 'add_term_relationship', array( $this, 'term_relationship_handler' ), 10, 2 ); add_action( 'delete_term_relationships', array( $this, 'term_relationships_handler' ), 10, 2 ); add_action( 'set_object_terms', array( $this, 'set_object_terms_handler' ), 10, 3 ); // Files if ( $this->is_main_site() ) { add_action( 'switch_theme', array( $this, 'theme_action_handler' ) ); add_action( 'activate_plugin', array( $this, 'plugin_action_handler' ) ); add_action( 'deactivate_plugin', array( $this, 'plugin_action_handler' ) ); } add_action( 'wp_handle_upload', array( $this, 'upload_handler' ) ); // Options add_action( 'deleted_option', array( $this, 'option_handler' ), 1 ); add_action( 'updated_option', array( $this, 'option_handler' ), 1 ); add_action( 'added_option', array( $this, 'option_handler' ), 1 ); $this->add_woocommerce_actions(); $this->add_vp_required_filters(); } function add_woocommerce_actions() { add_action( 'woocommerce_tax_rate_deleted', array( $this, 'woocommerce_tax_rate_handler' ), 10, 1 ); add_action( 'woocommerce_tax_rate_updated', array( $this, 'woocommerce_tax_rate_handler' ), 10, 1 ); add_action( 'woocommerce_tax_rate_added', array( $this, 'woocommerce_tax_rate_handler' ), 10, 1 ); add_action( 'woocommerce_new_order_item', array( $this, 'woocommerce_order_item_handler' ), 10, 1 ); add_action( 'woocommerce_update_order_item', array( $this, 'woocommerce_order_item_handler' ), 10, 1 ); add_action( 'woocommerce_delete_order_item', array( $this, 'woocommerce_order_item_handler' ), 10, 1 ); add_action( 'added_order_item_meta', array( $this, 'woocommerce_order_item_meta_handler' ), 10, 1 ); add_action( 'updated_order_item_meta', array( $this, 'woocommerce_order_item_meta_handler' ), 10, 1 ); add_action( 'deleted_order_item_meta', array( $this, 'woocommerce_order_item_meta_handler' ), 10, 1 ); add_action( 'woocommerce_attribute_added', array( $this, 'woocommerce_attribute_handler' ), 10, 1 ); add_action( 'woocommerce_attribute_updated', array( $this, 'woocommerce_attribute_handler' ), 10, 1 ); add_action( 'woocommerce_attribute_deleted', array( $this, 'woocommerce_attribute_handler' ), 10, 1 ); } function add_vp_required_filters() { // Log ins if ( $this->get_option( 'login_lockdown' ) ) { add_action( 'login_form', array( $this, 'add_js_token' ) ); add_filter( 'authenticate', array( $this, 'authenticate' ), 999 ); } // Report back to VaultPress add_action( 'shutdown', array( $this, 'do_pings' ) ); // VaultPress likes being first in line add_filter( 'pre_update_option_active_plugins', array( $this, 'load_first' ) ); } function get_jetpack_email() { if ( ! class_exists( 'Jetpack' ) ) { return false; } // For version of Jetpack prior to 7.7. if ( defined( 'JETPACK__VERSION' ) && version_compare( JETPACK__VERSION, '7.7', '<' ) && ! class_exists( 'Jetpack_IXR_Client' ) ) { Jetpack::load_xml_rpc_client(); } $xml = new Jetpack_IXR_Client( array( 'user_id' => get_current_user_id() ) ); $xml->query( 'wpcom.getUserEmail' ); if ( ! $xml->isError() ) { return $xml->getResponse(); } return new WP_Error( $xml->getErrorCode(), $xml->getErrorMessage() ); } function get_key_via_jetpack( $already_purchased = false ) { if ( ! class_exists( 'Jetpack' ) ) { return false; } // For version of Jetpack prior to 7.7. if ( defined( 'JETPACK__VERSION' ) && version_compare( JETPACK__VERSION, '7.7', '<' ) && ! class_exists( 'Jetpack_IXR_Client' ) ) { Jetpack::load_xml_rpc_client(); } $xml = new Jetpack_IXR_Client( array( 'user_id' => Jetpack_Options::get_option( 'master_user' ) ) ); $xml->query( 'vaultpress.registerSite', $already_purchased ); if ( ! $xml->isError() ) { return $xml->getResponse(); } return new WP_Error( $xml->getErrorCode(), $xml->getErrorMessage() ); } function register_via_jetpack( $already_purchased = false ) { $registration_key = $this->get_key_via_jetpack( $already_purchased ); if ( is_wp_error( $registration_key ) ) { return $registration_key; } return self::register( $registration_key ); } } $vaultpress = VaultPress::init(); if ( isset( $_GET['vaultpress'] ) && $_GET['vaultpress'] ) { if ( !function_exists( 'wp_magic_quotes' ) ) { // Escape with wpdb. $_GET = add_magic_quotes( $_GET ); $_POST = add_magic_quotes( $_POST ); $_COOKIE = add_magic_quotes( $_COOKIE ); $_SERVER = add_magic_quotes( $_SERVER ); // Force REQUEST to be GET + POST. If SERVER, COOKIE, or ENV are needed, use those superglobals directly. $_REQUEST = array_merge( $_GET, $_POST ); } else { wp_magic_quotes(); } if ( !function_exists( 'wp_get_current_user' ) ) include ABSPATH . '/wp-includes/pluggable.php'; // TODO: this prevents some error notices but do we need it? is there a better way to check capabilities/logged in user/etc? if ( function_exists( 'wp_cookie_constants' ) && !defined( 'AUTH_COOKIE' ) ) wp_cookie_constants(); $vaultpress->parse_request( null ); die(); } // only load hotfixes if it's not a VP request require_once __DIR__ . '/class.vaultpress-hotfixes.php'; $hotfixes = new VaultPress_Hotfixes(); // Add a helper method to WP CLI for auto-registerion via Jetpack if ( defined( 'WP_CLI' ) && WP_CLI ) { require_once __DIR__ . '/class.vaultpress-cli.php'; } require_once __DIR__ . '/cron-tasks.php'; Cote d’ Ivoire and Liberia both Launch National Immunisation Programmes for HPV (Human-Papillomavirus) - Social News XYZ
Social News XYZ     

Cote d’ Ivoire and Liberia both Launch National Immunisation Programmes for HPV (Human-Papillomavirus)

Posted By: December 4, 2019

Cote d’ Ivoire and Liberia both Launch National Immunisation Programmes for HPV (Human-Papillomavirus)
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MSD (www.MSD.co.za), known as Merck & Co., Inc., (NYSE: MRK) in the United States and Canada, congratulates both Cote d’ Ivoire and Liberia on the successful launch of the National Immunisation Programme (NIP) for the Human-Papillomavirus (HPV - the main cause of cervical cancer).[1]

Approximately 530 000 women are diagnosed with cervical cancer around the world each year.[2]  In Sub-Saharan Africa (SSA), cervical cancer incidence rates are the highest in the world (the prevalence of HPV in women with normal cytology is at an average of 24% in SSA) and the disease is the most common cause of cancer death among women in the region. [3]a,b  HPV16 and 18 are the most common genotypes in cervical cancer in SSA.3  Although HPV16 and 18 are associated with approximately 70% of cervical cancer cases [4], the various HPV genotypes also contribute to penile cancers, anal cancers, vulvar and vaginal cancers as well as genital warts (HPV6 and 11).3 

The launch of HPV programs in both Liberia and Cote d’ Ivoire

 

Cote d’ Ivoire has a population of 6.7 million women aged 15 years and older who are at risk of developing cervical cancer and Liberia has a population of 1.4 million women in this risk category.[5],6 Current estimates are that, annually, 1 789 women are diagnosed with cervical cancer and 1 448 die from the disease in Cote d’ Ivoire.[6]  In Liberia, there are 548 new cervical cancer cases annually and 449 cervical cancer deaths.5  Cervical cancer is the second most common cancer among women aged 15 to 44 years in Cote D’ Ivoire and the first most frequent cancer among women between 15 and 44 years of age in Liberia. 5,6

“We are excited that Cote d’ Ivoire and Liberia have launched their HPV immunisation programmes. MSD is committed to the elimination of preventable HPV related cancers and diseases and a national immunisation programme is a critical step towards that. Well done to both Cote d’ Ivoire and Liberia” said Dr Priya Agrawal – MD MSD South Africa and SSA Cluster.

[1] https://www.cdc.gov/cancer/cervical/pdf/cervical_facts.pdf

[2] https://www.sciencedirect.com/science/article/pii/S1877782116301084

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4144870/

[4] http://www.who.int/news-room/fact-sheets/detail/human-papillomavirus-(hpv)-and-cervical-cancer

[5] https://hpvcentre.net/statistics/reports/LBR.pdf

[6] https://hpvcentre.net/statistics/reports/CIV.pdf

Distributed by APO Group on behalf of MSD.Media Contacts:
Neren Rau
+27 11 655 3000
neren.rau@merck.com

Notes to Editors

About HPV and related cancers:
There are over 190 different types of HPV, and 40 of them affect the anogenital area. For most young individuals infected with HPV, the virus goes away on its own. If the virus does not go away it can develop into genital warts, pre-cancerous lesions, or even HPV related cancers such as cervical, vulvar, vaginal, anal, and penile cancer, depending on the HPV type. For more information, visit http://HPVvaccine.co.za/the-virus.html

About MSD:
For more than a century, MSD (www.MSD.co.za), a leading global biopharmaceutical company, has been inventing for life, bringing forward medicines and vaccines for the world’s most challenging diseases. MSD is a trade name of Merck & Co., Inc., with headquarters in Kenilworth, N.J., U.S.A. Through our prescription medicines, vaccines, biologic therapies and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to health care through far-reaching policies, programs and partnerships. Today, MSD continues to be at the forefront of research to advance the prevention and treatment of diseases that threaten people and communities around the world - including cancer, cardio-metabolic diseases, emerging animal diseases, Alzheimer’s disease and infectious diseases including HIV and Ebola.

For more information, visit www.MSD.co.za and connect with us on Twitter.

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Cote d’ Ivoire and Liberia both Launch National Immunisation Programmes for HPV (Human-Papillomavirus)

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