Third-placed Marseille went up after the half hour mark when two centre backs Adil Rami and Rolando connected well before the latter comfortably beat goalkeeper Anthony Lopes with a close-range shot, reports Xinhua news agency.
However, Rami conceded an own goal in the 42nd minute as he inadvertently deflected Maxwel Cornet's shot into the net.
Fourth-ranked Lyon turned the table seven minutes after the interval and Houssem Aouar curled in from the edge of the area after being teed up by Bertrand Traore.
In the 84th minute, Marseille substitute Kostas Mitroglou equalized with a header after a Dimitri Payet pass ricocheted off Jeremy Morel.
Depay, who came off the bench in the same minute as Mitroglou, was a decisive factor of the match as his header went over Mandanda and into the net just before the stoppage time.
Both teams were involved in a clash after the final whistle, before the incident was quickly dealt with after security staff came in for an intervention.
Earlier, PSG marched toward their fifth league title in six seasons with an almost unassailable 17-point lead with eight matches remaining.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
