On Thursday, Caen resisted the visitors' advantage in possession, before moving ahead in the 77th minute as midfielder Ismael Diomande headed home a Stef Peeters free kick, Xinhua news agency reported.
Caen secured a berth in French Cup semi-finals for the first time in the club's history.
They are set to meet a much tougher challenge in the upcoming fixture against three-time defending champions Paris Saint-Germain.
Paris Saint-Germain, who crushed Marseille 3-0 on Wednesday, are looking for a record-extending 12th French Cup.
Les Herbiers and Chambly, both from the third division, will meet in the other semi-final, ensuring that there will be at least one underdog in the final.
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