Former Afghan refugee Saeed Noori, 32, is due to appear before magistrates later on Saturday, reports the BBC.
He also faces one count of conduct endangering life.
More than a dozen people are still being treated in hospital after the incident in Flinders Street on Thursday.
Three are in a critical condition. Nine of the injured are foreign nationals from countries including South Korea, Ireland, Venezuela, China, India and Italy.
Melbourne police said the suspect was interviewed and charged after being released from hospital on Friday, the BBC reported.
However, security has been stepped up around the city.
The police said there would be a "highly visible" presence of officers at the fourth Ashes Test at the Melbourne Cricket Ground between Australia and England, which starts on December 26.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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