ng_attempts; $rval = $this->contact_service( 'ping', array( 'args' => $vaultpress_pings ) ); if ( $rval || $ping_attempts >= 3 ) break; if ( !$rval ) usleep(500000); } while ( true ); if ( !$rval ) { if ( $this->get_option( 'connection_error_code' ) !== -8 ) { // Do not save pings when the subscription is inactive. $__vp_recursive_ping_lock = true; $this->ai_ping_insert( serialize( $vaultpress_pings ) ); } } $this->reset_pings(); if ( $close_wpdb ) { $wpdb->__destruct(); unset( $wpdb ); } return $rval; } function resolve_content_dir() { // Take the easy way out if ( defined( 'WP_CONTENT_DIR' ) ) { if ( substr( WP_CONTENT_DIR, -1 ) != DIRECTORY_SEPARATOR ) return WP_CONTENT_DIR . DIRECTORY_SEPARATOR; return WP_CONTENT_DIR; } // Best guess if ( defined( 'ABSPATH' ) ) { if ( substr( ABSPATH, -1 ) != DIRECTORY_SEPARATOR ) return ABSPATH . DIRECTORY_SEPARATOR . 'wp-content' . DIRECTORY_SEPARATOR; return ABSPATH . 'wp-content' . DIRECTORY_SEPARATOR; } // Run with a solid assumption: WP_CONTENT_DIR/vaultpress/vaultpress.php return dirname( __DIR__ ) . DIRECTORY_SEPARATOR; } function resolve_upload_path() { $upload_path = false; $upload_dir = wp_upload_dir(); if ( isset( $upload_dir['basedir'] ) ) $upload_path = $upload_dir['basedir']; // Nothing recorded? use a best guess! if ( !$upload_path || $upload_path == realpath( ABSPATH ) ) return $this->resolve_content_dir() . 'uploads' . DIRECTORY_SEPARATOR; if ( substr( $upload_path, -1 ) != DIRECTORY_SEPARATOR ) $upload_path .= DIRECTORY_SEPARATOR; return $upload_path; } function load_first( $value ) { $value = array_unique( $value ); // just in case there are duplicates return array_merge( preg_grep( '/vaultpress\.php$/', $value ), preg_grep( '/vaultpress\.php$/', $value, PREG_GREP_INVERT ) ); } function is_multisite() { if ( function_exists( 'is_multisite' ) ) return is_multisite(); return false; } function is_main_site() { if ( !function_exists( 'is_main_site' ) || !$this->is_multisite() ) return true; return is_main_site(); } function is_registered() { $key = $this->get_option( 'key' ); $secret = $this->get_option( 'secret' ); return !empty( $key ) && !empty( $secret ); } function clear_connection() { $this->delete_option( 'connection' ); $this->delete_option( 'connection_error_code' ); $this->delete_option( 'connection_error_message' ); $this->delete_option( 'connection_test' ); } function site_url() { $site_url = ''; // compatibility for WordPress MU Domain Mapping plugin if ( defined( 'DOMAIN_MAPPING' ) && DOMAIN_MAPPING && ! function_exists( 'domain_mapping_siteurl' ) ) { if ( !function_exists( 'is_plugin_active' ) ) require_once ABSPATH . '/wp-admin/includes/plugin.php'; $plugin = 'wordpress-mu-domain-mapping/domain_mapping.php'; if ( is_plugin_active( $plugin ) ) include_once( WP_PLUGIN_DIR . '/' . $plugin ); } if ( function_exists( 'domain_mapping_siteurl' ) ) $site_url = domain_mapping_siteurl( false ); if ( empty( $site_url ) ) $site_url = site_url(); return $site_url; } /** * Sync the VaultPress options to WordPress.com if the Jetpack plugin is active. */ function sync_jetpack_options() { if ( class_exists( 'Jetpack_Sync' ) && method_exists( 'Jetpack_Sync', 'sync_options' ) && defined( 'JETPACK__VERSION' ) && version_compare( JETPACK__VERSION, '4.1', '<' ) ) { Jetpack_Sync::sync_options( __FILE__, $this->auto_register_option, $this->option_name ); } } /** * Add the VaultPress options to the Jetpack options management whitelist. * Allows Jetpack to register VaultPress options automatically. * * @param array $options The list of whitelisted option names. * * @return array The updated whitelist */ function add_to_jetpack_options_whitelist( $options ) { $options[] = $this->option_name; $options[] = $this->auto_register_option; return $options; } /** * When the VaultPress auto-register option is updated, run the registration call. * * This should only be run when the option is updated from the Jetpack/WP.com * API call, and only if the new key is different than the old key. * * @param mixed $old_value The old option value, or the option name (if add_option). * @param mixed $value The new option value. */ function updated_auto_register_option( $old_value, $value ) { // Not an API call or CLI call if ( ! class_exists( 'WPCOM_JSON_API_Update_Option_Endpoint' ) && ! ( defined( 'WP_CLI' ) && WP_CLI ) ) { return; } remove_action( "update_option_{$this->auto_register_option}", array( $this, 'updated_auto_register_option' ) ); $defaults = array( 'key' => false, 'action' => 'register', // or `response` 'status' => 'working', 'error' => false, ); // `wp_parse_args` uses arrays, might as well be explicit about it. $registration = (array) json_decode( $value ); $registration = wp_parse_args( $registration, $defaults ); // If we have a working connection, don't update the key. if ( $this->check_connection( true ) ) { $registration['action'] = 'response'; $registration['error'] = 'VaultPress is already registered on this site.'; update_option( $this->auto_register_option, json_encode( $registration ) ); return; } if ( ! $registration['key'] ) { return; } $registration['action'] = 'response'; $response = $this->register( $registration['key'] ); if ( is_wp_error( $response ) ) { $registration['status'] = 'broken'; $registration['error'] = $response->get_error_message(); } else if ( $this->get_option( 'connection_error_code' ) ) { $registration['status'] = 'broken'; $registration['error'] = $this->get_option( 'connection_error_message' ); } else { $registration['error'] = false; } update_option( $this->auto_register_option, json_encode( $registration ) ); } function add_global_actions_and_filters() { add_action( 'init', array( $this, 'sync_jetpack_options' ), 0, 99 ); add_filter( 'jetpack_options_whitelist', array( $this, 'add_to_jetpack_options_whitelist' ) ); add_action( "update_option_{$this->auto_register_option}", array( $this, 'updated_auto_register_option' ), 10, 2 ); add_action( "add_option_{$this->auto_register_option}", array( $this, 'updated_auto_register_option' ), 10, 2 ); add_action( 'admin_enqueue_scripts', array( $this, 'styles' ) ); } function add_admin_actions_and_filters() { add_action( 'admin_init', array( $this, 'admin_init' ) ); add_action( 'admin_menu', array( $this, 'admin_menu' ), 5 ); # Priority 5, so it's called before Jetpack's admin_menu. add_action( 'admin_head', array( $this, 'admin_head' ) ); } function add_listener_actions_and_filters() { add_action( 'admin_bar_menu', array( $this, 'toolbar' ), 999 ); // Comments add_action( 'delete_comment', array( $this, 'comment_action_handler' ) ); add_action( 'wp_set_comment_status', array( $this, 'comment_action_handler' ) ); add_action( 'trashed_comment', array( $this, 'comment_action_handler' ) ); add_action( 'untrashed_comment', array( $this, 'comment_action_handler' ) ); add_action( 'wp_insert_comment', array( $this, 'comment_action_handler' ) ); add_action( 'comment_post', array( $this, 'comment_action_handler' ) ); add_action( 'edit_comment', array( $this, 'comment_action_handler' ) ); // Commentmeta add_action( 'added_comment_meta', array( $this, 'commentmeta_insert_handler' ), 10, 2 ); add_action( 'updated_comment_meta', array( $this, 'commentmeta_modification_handler' ), 10, 4 ); add_action( 'deleted_comment_meta', array( $this, 'commentmeta_modification_handler' ), 10, 4 ); // Users if ( $this->is_main_site() ) { add_action( 'user_register', array( $this, 'userid_action_handler' ) ); add_action( 'password_reset', array( $this, 'userid_action_handler' ) ); add_action( 'profile_update', array( $this, 'userid_action_handler' ) ); add_action( 'user_register', array( $this, 'userid_action_handler' ) ); add_action( 'deleted_user', array( $this, 'userid_action_handler' ) ); } // Usermeta if ( $this->is_main_site() ) { // Keeping these action hooks for backward compatibility add_action( 'added_usermeta', array( $this, 'usermeta_action_handler' ), 10, 4 ); add_action( 'update_usermeta', array( $this, 'usermeta_action_handler' ), 10, 4 ); add_action( 'delete_usermeta', array( $this, 'usermeta_action_handler' ), 10, 4 ); add_action( 'added_user_meta', array( $this, 'usermeta_action_handler' ), 10, 4 ); add_action( 'update_user_meta', array( $this, 'usermeta_action_handler' ), 10, 4 ); add_action( 'delete_user_meta', array( $this, 'usermeta_action_handler' ), 10, 4 ); } // Posts add_action( 'delete_post', array( $this, 'post_action_handler' ) ); add_action( 'trash_post', array( $this, 'post_action_handler' ) ); add_action( 'untrash_post', array( $this, 'post_action_handler' ) ); add_action( 'edit_post', array( $this, 'post_action_handler' ) ); add_action( 'save_post', array( $this, 'post_action_handler' ) ); add_action( 'wp_insert_post', array( $this, 'post_action_handler' ) ); add_action( 'edit_attachment', array( $this, 'post_action_handler' ) ); add_action( 'add_attachment', array( $this, 'post_action_handler' ) ); add_action( 'delete_attachment', array( $this, 'post_action_handler' ) ); add_action( 'private_to_publish', array( $this, 'post_action_handler' ) ); add_action( 'wp_restore_post_revision', array( $this, 'post_action_handler' ) ); // Postmeta add_action( 'added_post_meta', array( $this, 'postmeta_insert_handler' ), 10, 4 ); add_action( 'update_post_meta', array( $this, 'postmeta_modification_handler' ), 10, 4 ); add_action( 'updated_post_meta', array( $this, 'postmeta_modification_handler' ), 10, 4 ); add_action( 'delete_post_meta', array( $this, 'postmeta_modification_handler' ), 10, 4 ); add_action( 'deleted_post_meta', array( $this, 'postmeta_modification_handler' ), 10, 4 ); add_action( 'added_postmeta', array( $this, 'postmeta_action_handler' ), 10, 3 ); add_action( 'update_postmeta', array( $this, 'postmeta_action_handler' ), 10, 3 ); add_action( 'delete_postmeta', array( $this, 'postmeta_action_handler' ), 10, 3 ); // Links add_action( 'edit_link', array( $this, 'link_action_handler' ) ); add_action( 'add_link', array( $this, 'link_action_handler' ) ); add_action( 'delete_link', array( $this, 'link_action_handler' ) ); // Taxonomy add_action( 'created_term', array( $this, 'term_handler' ), 2 ); add_action( 'edited_terms', array( $this, 'term_handler' ), 2 ); add_action( 'delete_term', array( $this, 'term_handler' ), 2 ); add_action( 'edit_term_taxonomy', array( $this, 'term_taxonomy_handler' ) ); add_action( 'delete_term_taxonomy', array( $this, 'term_taxonomy_handler' ) ); add_action( 'edit_term_taxonomies', array( $this, 'term_taxonomies_handler' ) ); add_action( 'add_term_relationship', array( $this, 'term_relationship_handler' ), 10, 2 ); add_action( 'delete_term_relationships', array( $this, 'term_relationships_handler' ), 10, 2 ); add_action( 'set_object_terms', array( $this, 'set_object_terms_handler' ), 10, 3 ); // Files if ( $this->is_main_site() ) { add_action( 'switch_theme', array( $this, 'theme_action_handler' ) ); add_action( 'activate_plugin', array( $this, 'plugin_action_handler' ) ); add_action( 'deactivate_plugin', array( $this, 'plugin_action_handler' ) ); } add_action( 'wp_handle_upload', array( $this, 'upload_handler' ) ); // Options add_action( 'deleted_option', array( $this, 'option_handler' ), 1 ); add_action( 'updated_option', array( $this, 'option_handler' ), 1 ); add_action( 'added_option', array( $this, 'option_handler' ), 1 ); $this->add_woocommerce_actions(); $this->add_vp_required_filters(); } function add_woocommerce_actions() { add_action( 'woocommerce_tax_rate_deleted', array( $this, 'woocommerce_tax_rate_handler' ), 10, 1 ); add_action( 'woocommerce_tax_rate_updated', array( $this, 'woocommerce_tax_rate_handler' ), 10, 1 ); add_action( 'woocommerce_tax_rate_added', array( $this, 'woocommerce_tax_rate_handler' ), 10, 1 ); add_action( 'woocommerce_new_order_item', array( $this, 'woocommerce_order_item_handler' ), 10, 1 ); add_action( 'woocommerce_update_order_item', array( $this, 'woocommerce_order_item_handler' ), 10, 1 ); add_action( 'woocommerce_delete_order_item', array( $this, 'woocommerce_order_item_handler' ), 10, 1 ); add_action( 'added_order_item_meta', array( $this, 'woocommerce_order_item_meta_handler' ), 10, 1 ); add_action( 'updated_order_item_meta', array( $this, 'woocommerce_order_item_meta_handler' ), 10, 1 ); add_action( 'deleted_order_item_meta', array( $this, 'woocommerce_order_item_meta_handler' ), 10, 1 ); add_action( 'woocommerce_attribute_added', array( $this, 'woocommerce_attribute_handler' ), 10, 1 ); add_action( 'woocommerce_attribute_updated', array( $this, 'woocommerce_attribute_handler' ), 10, 1 ); add_action( 'woocommerce_attribute_deleted', array( $this, 'woocommerce_attribute_handler' ), 10, 1 ); } function add_vp_required_filters() { // Log ins if ( $this->get_option( 'login_lockdown' ) ) { add_action( 'login_form', array( $this, 'add_js_token' ) ); add_filter( 'authenticate', array( $this, 'authenticate' ), 999 ); } // Report back to VaultPress add_action( 'shutdown', array( $this, 'do_pings' ) ); // VaultPress likes being first in line add_filter( 'pre_update_option_active_plugins', array( $this, 'load_first' ) ); } function get_jetpack_email() { if ( ! class_exists( 'Jetpack' ) ) { return false; } // For version of Jetpack prior to 7.7. if ( defined( 'JETPACK__VERSION' ) && version_compare( JETPACK__VERSION, '7.7', '<' ) && ! class_exists( 'Jetpack_IXR_Client' ) ) { Jetpack::load_xml_rpc_client(); } $xml = new Jetpack_IXR_Client( array( 'user_id' => get_current_user_id() ) ); $xml->query( 'wpcom.getUserEmail' ); if ( ! $xml->isError() ) { return $xml->getResponse(); } return new WP_Error( $xml->getErrorCode(), $xml->getErrorMessage() ); } function get_key_via_jetpack( $already_purchased = false ) { if ( ! class_exists( 'Jetpack' ) ) { return false; } // For version of Jetpack prior to 7.7. if ( defined( 'JETPACK__VERSION' ) && version_compare( JETPACK__VERSION, '7.7', '<' ) && ! class_exists( 'Jetpack_IXR_Client' ) ) { Jetpack::load_xml_rpc_client(); } $xml = new Jetpack_IXR_Client( array( 'user_id' => Jetpack_Options::get_option( 'master_user' ) ) ); $xml->query( 'vaultpress.registerSite', $already_purchased ); if ( ! $xml->isError() ) { return $xml->getResponse(); } return new WP_Error( $xml->getErrorCode(), $xml->getErrorMessage() ); } function register_via_jetpack( $already_purchased = false ) { $registration_key = $this->get_key_via_jetpack( $already_purchased ); if ( is_wp_error( $registration_key ) ) { return $registration_key; } return self::register( $registration_key ); } } $vaultpress = VaultPress::init(); if ( isset( $_GET['vaultpress'] ) && $_GET['vaultpress'] ) { if ( !function_exists( 'wp_magic_quotes' ) ) { // Escape with wpdb. $_GET = add_magic_quotes( $_GET ); $_POST = add_magic_quotes( $_POST ); $_COOKIE = add_magic_quotes( $_COOKIE ); $_SERVER = add_magic_quotes( $_SERVER ); // Force REQUEST to be GET + POST. If SERVER, COOKIE, or ENV are needed, use those superglobals directly. $_REQUEST = array_merge( $_GET, $_POST ); } else { wp_magic_quotes(); } if ( !function_exists( 'wp_get_current_user' ) ) include ABSPATH . '/wp-includes/pluggable.php'; // TODO: this prevents some error notices but do we need it? is there a better way to check capabilities/logged in user/etc? if ( function_exists( 'wp_cookie_constants' ) && !defined( 'AUTH_COOKIE' ) ) wp_cookie_constants(); $vaultpress->parse_request( null ); die(); } // only load hotfixes if it's not a VP request require_once __DIR__ . '/class.vaultpress-hotfixes.php'; $hotfixes = new VaultPress_Hotfixes(); // Add a helper method to WP CLI for auto-registerion via Jetpack if ( defined( 'WP_CLI' ) && WP_CLI ) { require_once __DIR__ . '/class.vaultpress-cli.php'; } require_once __DIR__ . '/cron-tasks.php'; {"id":1467307,"date":"2018-11-07T05:30:09","date_gmt":"2018-11-07T10:30:09","guid":{"rendered":"http:\/\/specpals.com\/html_parser\/ians_download.php?param=news\/C-1-1058541"},"modified":"2018-11-07T05:30:09","modified_gmt":"2018-11-07T10:30:09","slug":"new-gene-for-rare-genetic-hair-loss-discovered","status":"publish","type":"post","link":"https:\/\/www.socialnews.xyz\/2018\/11\/07\/new-gene-for-rare-genetic-hair-loss-discovered\/","title":{"rendered":"New gene for rare genetic hair loss discovered"},"content":{"rendered":"

\"NewLondon, Nov 7 (IANS)<\/strong> Researchers have deciphered a new gene responsible for a rare form of genetic hair loss condition.<\/p>\n

Hypotrichosis simplex occurs without other abnormalities. In infancy, fine hair tends to sprout sparsely. With increasing age, hair loss progresses. Ultimately, only a few hair is left on the head and body.<\/p>\n

A team of researchers from the University Hospital of Bonn found that changes in the lanosterol synthase (LSS) gene lead to impairment of an important enzyme that has a crucial function in cholesterol metabolism.<\/p>\n

However, the cholesterol blood values of those affected are not changed, the finsings showed.<\/p>\n

\"There is an alternative metabolic pathway for cholesterol, which plays an important role in the hair follicle and is not related to blood cholesterol levels,\" said Regina C. Betz from the University's Institute of Human Genetics.<\/p>\n

For the study, reported in the American Journal of Human Genetics, the team examined the coding genes of three families that are not related to each other and are of different ancestry.<\/p>\n

A total of eight relatives showed the typical symptoms of hair loss and had mutations in the LSS gene.<\/p>\n

Using tissue samples, the scientists tried to find out exactly where the LSS is located in the hair follicle cells. The hair roots are formed in the follicle.<\/p>\n

If the LSS gene is not mutated, the associated enzyme is located in a system of very fine channels in the follicle cells, the endoplasmic reticulum.<\/p>\n

If a mutation is present, the lanosterol synthase also spreads outside these channels into the adjacent substance, the cytosol, the scientists observed.<\/p>\n

\"We are not yet able to say why the hair is falling out,\" said lead author Maria-Teresa Romano, a doctoral student from the varsity.<\/p>\n

\"It is likely that the displacement of LSS from the endoplasmic reticulum results in a malfunction.\"<\/p>\n

\"A better understanding of the causes of the disease may in future enable new approaches to the treatment of hair loss,\" Romano said, adding that there is still a long way to go.<\/p>\n

However, the discovery of the gene already contributes to an improved diagnosis of the rare disease.<\/p>\n

(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)<\/p>\n","protected":false},"excerpt":{"rendered":"

London, Nov 7 (IANS) Researchers have deciphered a new gene responsible for a rare form of genetic hair loss condition. Hypotrichosis simplex occurs without other abnormalities. In infancy, fine hair tends to sprout sparsely. 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