The US embassy complex is in Beijing's Chaoyang District.
Witnesses have posted images on Twitter of smoke surrounding the building. A bystander said there had been injuries, the Herald Sun reported.
The explosion occurred around 1 p.m. in an area where many Chinese citizens line up each day to apply for visas, The New York Times reported.
According to Chinese media reports, a witness said police took away a woman spraying petrol on herself in a suspected attempt at self-immolation.
Photos and videos emerging online of the explosion on Chinese social media site Weibo showed smoke billowing from the area with police creating a roadblock around a vehicle, Hong Kong Free Press said.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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