Diego Souza gave Sao Paulo the lead at America's Independencia stadium in Belo Horizonte on Sunday but Rafael Moura equalised minutes later, reports Xinhua news agency.
Thirty five-year-old Nene then struck twice in 13 minutes to guarantee the six-time champions their third win from seven matches this campaign.
Meanwhile, Bruno Silva scored in the 75th minute to hand Cruzeiro a 1-0 away victory over Santos.
In Fortaleza, 20-year-old midfielder Thonny Anderson netted nine minutes from time as Gremio won 1-0 at Cear?.
In other matches, Atletico Paranaense drew 0-0 at Parana, Bahia routed Vasco da Gama at home 3-0, Vitoria drew 1-1 at Botafogo and hosts Internacional beat Corinthians 1-0.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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