The plane came down in the Zagros mountains near the city of Semirom in Isfahan province while flying between Tehran and the south-western city of Yasuj, reports the BBC.
"All emergency forces are on alert," an emergency services spokesman said.
However, there was no official confirmation on the number of casualties.
The plane, believed to be an ATR 72-500, was operated by Aseman Airlines.
According to local media reports, the people on board were 60 passengers, two security guards, two flight attendants, the pilot and co-pilot.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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