Edward Zenteno struck early for the hosts at the Felix Capriles stadium before Gilbert Alvarez and Cristhian Machado netted in the second half on Thursday, reports Xinhua news agency..
The return leg will be played at River's Monumental stadium in Buenos Aires next Thursday.
Jorge Wilstermann's only appearance in the Copa Libertadores semifinals was a 4-1 to Brazil's Flamengo in the 1981 tournament. River Plate have won South America's top club competition three times.
The winner of the Copa Libertadores will earn a berth at the FIFA Club World Cup in the United Arab Emirates in December.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
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