The toll was confirmed to the BBC by the senior regional official.
However, no civilians were killed in the explosion, he added.
The GBU-43, a non-nuclear, 10-tonne missile powered by a wave of air pressure, was dropped on Thursday onto caves used by the terror group in Achin district.
The Chief Executive of Afghanistan, Abdullah Abdullah, said the attack had been carried out in co-ordination with his government and "great care had been taken to avoid civilian harm".
After the strike, General John Nicholson, the most senior US military commander in Afghanistan, said: "The enemy had created bunkers, tunnels and extensive mine fields, and this weapon was used to reduce those obstacles so that we could continue our offensive in southern Nangarhar."
On Friday, the Pentagon released video footage of the moment the GBU-43 bomb destroyed the caves and tunnels with an explosive power equivalent to 11 tonnes of TNT, Efe news reported.
(This story has not been edited by Social News XYZ staff and is auto-generated from a syndicated feed.)
Doraiah Chowdary Vundavally is a Software engineer at VTech . He is the news editor of SocialNews.XYZ and Freelance writer-contributes Telugu and English Columns on Films, Politics, and Gossips. He is the primary contributor for South Cinema Section of SocialNews.XYZ. His mission is to help to develop SocialNews.XYZ into a News website that has no bias or judgement towards any.
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