The experience of Iranians about the failure of the US in the fulfilment of its obligations pertaining to a nuclear deal signed on July 14 showed that it can never be trusted, Xinhua news agency quoted Khamenei as saying.
"The US has violated its obligations (over the nuclear deal) and is busy destroying Iran's economic ties with other countries," he said.
Khamenei also accused Saudi Arabia of committing a "grave crime" by bombing innocent people in Yemen.
"Raiding Yemen, uninterrupted bombing of homes, hospitals and schools, and the killing of children are a grave crime of Saudi Arabia which is done by the green light of the US," Khamenei said.
He described the recent negotiations of Saudi Arabia with Israel as a "dagger from behind", saying "Saudi relations with Israel are a big sin and a treason".
In building Saudi ties with Israel, "the US has played a role, as the Saudi officials are obsessed by the whims of the Americans", he said.
The Iranian leader said Saudi Arabia had raided Bahrain with the help of the US.
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